Microbiology
Vivexia has developed a wide range of services that are essential to the in vitro evaluation of your anti-infective compounds and to the characterization of their pharmacokinetics:
- Minimum Inhibitory Concentrations (MIC) (macrodilution, microdilution, agar diffusion, Etest), Minimum Bactericidal Concentrations (MBC) – in accordance with current official recommendations (CLSI / EUCAST / BSAC)
- Time-kill curves
- Post-Antibiotic Effect (PAE)
- Mutant Prevention Concentration (MPC)
- Fractional Inhibitory Concentration (FIC) index (measurement of synergic, adverse or additive effects)
- Microbiological analyses on various biological samples:
- Determination of the bacterial load in the blood, lungs, kidneys, spleen, liver, bones, skin, cerebrospinal fluid, peritoneal fluid, urine, faeces (digestive decontamination or growth of particular bacterial populations)…
- Detection of resistant mutants
- Titration of bacteriophages
- Quantification of the bacterial biofilm and evaluation of the anti-biofilm potential of compounds.
- Production of standardized batches of bacterial cultures (aerobic or anaerobic species/microbiota), yeasts, dermatophytes
- Bacterial identification by MALDI-TOF-MS
- Determination of antibiotic concentrations in biological serum and fluids using different techniques (microbiological dosages, HPLC/MS-MS, immuno-analyses etc.)
- Determination of plasma protein binding
