Validated in vitro techniques at the service of our clients

Antimicrobial / antibiofilm efficacy

• Antibiogram
• Minimum Inhibitory Concentration (MIC) – liquid or solid method
• Minimum Bactericidal Concentration (MBC)
• Time Kill Curve (TKC)
• Fractionated Inhibitory Concentration (FIC) : synergic, adverse or additive effects
• Mutant Prevention Concentration (MPC)
• Ex vivo bacterial quantification, mutants investigation
• Bacterial identification (MALDI-TOF)
• Biofilm quantification / assessment of antibiofilm properties
• Titration of phages suspensions

Pharmacological and biological assays

• Determination of antibiotic concentrations in different biological matrices (serum, bone tissue, broncho-alveolar fluid, cerebrospinal fluid), using various techniques (microbiological assays, HPLC/MS-MS, immuno-analyses etc.)
• Determination of plasma protein binding
• Biochemical and hematological analyses

Antibacterial activity of non porous surfaces

• ISO 22196 standard method
• Bacterial references strains : Staphylococcus aureus, Escherichia coli
• According to customer request, other species and other standard methods can be investigated

Histopathological and microscopic analyses

• Tissue compatibility / local tolerance (e.g. following a medical device implantation, according to ISO 10993-6 standard)
• Activity of anti-infective compounds on the histological structure of different organs
• Biofilm characterization using the full-field OCT technique

 Microbiota

• Production of standardized batches of bacterial suspensions (aerobic or anaerobic species/microbiota), yeasts, dermatophytes
• Digestive bacterial contamination / decontamination
• Development of partnerships to support the impact of microbiome-based therapeutics on various pathologies (cancer, inflammation, infection etc.)

Collaboration with Oncodesign

https://www.oncodesign-services.com/microbiome/

Using Individual or a consortium of bacteria for immuno-oncology research