Validated in vitro techniques at the service of our clients

Vivexia provides a wide range of in vitro services and supports the assessment of your anti-infective compounds, according to the current recommendations (CLSI, CA-SFM/EUCAST).

Antimicrobial / antibiofilm efficacy

  • Antibiogram
  • Minimum Inhibitory Concentration (MIC) – liquid or solid method
  • Minimum Bactericidal Concentration (MBC)
  • Time Kill Curve (TKC)
  • Fractionated Inhibitory Concentration (FIC) : synergic, adverse or additive effects
  • Mutant Prevention Concentration (MPC)
  • Ex vivo bacterial quantification, mutants investigation
  • Bacterial identification (MALDI-TOF)
  • Biofilm quantification / assessment of antibiofilm properties
  • Titration of phages suspensions

Pharmacological and biological assays

  • Determination of antibiotic concentrations in different biological matrices (serum, bone tissue, broncho-alveolar fluid, cerebrospinal fluid), using various techniques (microbiological assays, HPLC/MS-MS, immuno-analyses etc.)
  • Determination of plasma protein binding
  • Biochemical and hematological analyses

Antibacterial activity of non porous surfaces

  • ISO 22196 standard method
  • Bacterial references strains : Staphylococcus aureus, Escherichia coli
  • According to customer request, other species and other standard methods can be investigated

Histopathological and microscopic analyses

  • Tissue compatibility / local tolerance (e.g. following a medical device implantation, according to ISO 10993-6 standard)
  • Activity of anti-infective compounds on the histological structure of different organs
  • Biofilm characterization using the full-field OCT technique


  • Production of standardized batches of bacterial suspensions (aerobic or anaerobic species/microbiota), yeasts, dermatophytes
  • Digestive bacterial contamination / decontamination
  • Development of partnerships to support the impact of microbiome-based therapeutics on various pathologies (cancer, inflammation, infection etc.)