In vivo models that are highly predictive to human pharmacodynamics.

Vivexia’s in vivo expertise in the pharmacology of anti-infective drugs allows us to assess the pre clinical efficacy of the incoming treatments.

Our models (mouse, rat, rabbit) cover the numerous stages of pre clinical development (from screening to the precise determination of the pharmacodynamics parameters associated with efficacy or failure).

They are perfectly suited to the evaluation of a wide range of anti-infective drugs (peptides, small biological molecules, vaccines, natural products, bacteriophages, etc.).

PK/ PD studies

  • Pharmacokinetic studies (PK) and bioanalyses
  • Modeling and simulation of human PK
  • Recommendations for treatment regimens
  • Pharmacodynamic (PD) modeling

Exploratory toxicity assessment

  • Acute toxicity (MTD, LD50, LD100)
  • Biological tolerance (ISO 10993-11 standard method)
  • Toxicity following repeated doses
Our models
(hover over the body to explore them)
See the full list of models

Tous nos modèles

Baterial species Resistance mechanism Animal species Document
Acinetobacter baumanniiCRABMouse
Acinetobacter baumanniiCarba R (OXA-40)Mouse
Acinetobacter baumanniiCarba R (OXA-23)Mouse
Acinetobacter baumanniiCarba R (OXA-58)Mouse
Acinetobacter baumanniiCarba R / Colistin RMouse
Escherichia coliShiga ToxinRabbit
Escherichia coliATCC 25922Mouse
Escherichia coliC5Rat new-born
Haemophilus influenzaenon-type b, beta-lactamase -Rabbit
Haemophilus influenzaenon-type b, beta-lactamase +Rabbit
Klebsiella pneumoniaePUG-2 (cefotaxime-R)Mouse
Klebsiella pneumoniaeBAA 2470 (NDM-1)Mouse
Klebsiella pneumoniaeATCC BAA 2470 (NDM-1)Rabbit
Klebsiella pneumoniae27908M (KPC-2)Rabbit
Klebsiella pneumoniaeBAA 2470 (NDM-1)Mouse
Klebsiella pneumoniaeBAA 1905 (KPC-2)Mouse
Pseudomonas aeruginosaPA14Rabbit
Pseudomonas aeruginosaPAO1Rabbit
Pseudomonas aeruginosaPAO1 MexXY (efflux aminosides)Rabbit
Pseudomonas aeruginosaDSM 1117Mouse
Staphylococcus aureusATCC 29213 (MSSA)Mouse
Staphylococcus aureusATCC 43300 (MRSA)Mouse
Staphylococcus aureusATCC 29213 (MSSA)Mouse
Staphylococcus aureusclinical strainsMouse
Staphylococcus aureusATCC 43300 (MRSA)Mouse
Staphylococcus aureusclinical strain (osteomyelitis) - MSSAMouse (titanium implant)
Staphylococcus aureusclinical MSSAMouse
Staphylococcus aureusLac USA300 PVL+ / PVL-Rabbit
Staphylococcus aureusSF8300 PVL+ (CA-MRSA)Rabbit
Staphylococcus aureusHA-MRSA (PVL-/Hla++)Mouse
Staphylococcus aureusATCC 29213 (MSSA)Mouse
Staphylococcus epidermidisclinical strain (osteomyelitis) MSSE / MRSERat (No implant)
Streptococcus pneumoniaeQuinolones resistanceRabbit
Streptococcus pneumoniaeC3G resistanceRabbit